class Akismet_REST_API { /** * Register the REST API routes. */ public static function init() { if ( ! function_exists( 'register_rest_route' ) ) { // The REST API wasn't integrated into core until 4.4, and we support 4.0+ (for now). return false; } register_rest_route( 'akismet/v1', '/key', array( array( 'methods' => WP_REST_Server::READABLE, 'permission_callback' => array( 'Akismet_REST_API', 'privileged_permission_callback' ), 'callback' => array( 'Akismet_REST_API', 'get_key' ), ), array( 'methods' => WP_REST_Server::EDITABLE, 'permission_callback' => array( 'Akismet_REST_API', 'privileged_permission_callback' ), 'callback' => array( 'Akismet_REST_API', 'set_key' ), 'args' => array( 'key' => array( 'required' => true, 'type' => 'string', 'sanitize_callback' => array( 'Akismet_REST_API', 'sanitize_key' ), 'description' => __( 'A 12-character Akismet API key. Available at akismet.com/get/', 'akismet' ), ), ), ), array( 'methods' => WP_REST_Server::DELETABLE, 'permission_callback' => array( 'Akismet_REST_API', 'privileged_permission_callback' ), 'callback' => array( 'Akismet_REST_API', 'delete_key' ), ) ) ); register_rest_route( 'akismet/v1', '/settings/', array( array( 'methods' => WP_REST_Server::READABLE, 'permission_callback' => array( 'Akismet_REST_API', 'privileged_permission_callback' ), 'callback' => array( 'Akismet_REST_API', 'get_settings' ), ), array( 'methods' => WP_REST_Server::EDITABLE, 'permission_callback' => array( 'Akismet_REST_API', 'privileged_permission_callback' ), 'callback' => array( 'Akismet_REST_API', 'set_boolean_settings' ), 'args' => array( 'akismet_strictness' => array( 'required' => false, 'type' => 'boolean', 'description' => __( 'If true, Akismet will automatically discard the worst spam automatically rather than putting it in the spam folder.', 'akismet' ), ), 'akismet_show_user_comments_approved' => array( 'required' => false, 'type' => 'boolean', 'description' => __( 'If true, show the number of approved comments beside each comment author in the comments list page.', 'akismet' ), ), ), ) ) ); register_rest_route( 'akismet/v1', '/stats', array( 'methods' => WP_REST_Server::READABLE, 'permission_callback' => array( 'Akismet_REST_API', 'privileged_permission_callback' ), 'callback' => array( 'Akismet_REST_API', 'get_stats' ), 'args' => array( 'interval' => array( 'required' => false, 'type' => 'string', 'sanitize_callback' => array( 'Akismet_REST_API', 'sanitize_interval' ), 'description' => __( 'The time period for which to retrieve stats. Options: 60-days, 6-months, all', 'akismet' ), 'default' => 'all', ), ), ) ); register_rest_route( 'akismet/v1', '/stats/(?P[\w+])', array( 'args' => array( 'interval' => array( 'description' => __( 'The time period for which to retrieve stats. Options: 60-days, 6-months, all', 'akismet' ), 'type' => 'string', ), ), array( 'methods' => WP_REST_Server::READABLE, 'permission_callback' => array( 'Akismet_REST_API', 'privileged_permission_callback' ), 'callback' => array( 'Akismet_REST_API', 'get_stats' ), ) ) ); register_rest_route( 'akismet/v1', '/alert', array( array( 'methods' => WP_REST_Server::READABLE, 'permission_callback' => array( 'Akismet_REST_API', 'remote_call_permission_callback' ), 'callback' => array( 'Akismet_REST_API', 'get_alert' ), 'args' => array( 'key' => array( 'required' => false, 'type' => 'string', 'sanitize_callback' => array( 'Akismet_REST_API', 'sanitize_key' ), 'description' => __( 'A 12-character Akismet API key. Available at akismet.com/get/', 'akismet' ), ), ), ), array( 'methods' => WP_REST_Server::EDITABLE, 'permission_callback' => array( 'Akismet_REST_API', 'remote_call_permission_callback' ), 'callback' => array( 'Akismet_REST_API', 'set_alert' ), 'args' => array( 'key' => array( 'required' => false, 'type' => 'string', 'sanitize_callback' => array( 'Akismet_REST_API', 'sanitize_key' ), 'description' => __( 'A 12-character Akismet API key. Available at akismet.com/get/', 'akismet' ), ), ), ), array( 'methods' => WP_REST_Server::DELETABLE, 'permission_callback' => array( 'Akismet_REST_API', 'remote_call_permission_callback' ), 'callback' => array( 'Akismet_REST_API', 'delete_alert' ), 'args' => array( 'key' => array( 'required' => false, 'type' => 'string', 'sanitize_callback' => array( 'Akismet_REST_API', 'sanitize_key' ), 'description' => __( 'A 12-character Akismet API key. Available at akismet.com/get/', 'akismet' ), ), ), ) ) ); register_rest_route( 'akismet/v1', '/webhook', array( 'methods' => WP_REST_Server::CREATABLE, 'callback' => array( 'Akismet_REST_API', 'receive_webhook' ), 'permission_callback' => array( 'Akismet_REST_API', 'remote_call_permission_callback' ), ) ); } /** * Get the current Akismet API key. * * @param WP_REST_Request $request * @return WP_Error|WP_REST_Response */ public static function get_key( $request = null ) { return rest_ensure_response( Akismet::get_api_key() ); } /** * Set the API key, if possible. * * @param WP_REST_Request $request * @return WP_Error|WP_REST_Response */ public static function set_key( $request ) { if ( defined( 'WPCOM_API_KEY' ) ) { return rest_ensure_response( new WP_Error( 'hardcoded_key', __( 'This site\'s API key is hardcoded and cannot be changed via the API.', 'akismet' ), array( 'status'=> 409 ) ) ); } $new_api_key = $request->get_param( 'key' ); if ( ! self::key_is_valid( $new_api_key ) ) { return rest_ensure_response( new WP_Error( 'invalid_key', __( 'The value provided is not a valid and registered API key.', 'akismet' ), array( 'status' => 400 ) ) ); } update_option( 'wordpress_api_key', $new_api_key ); return self::get_key(); } /** * Unset the API key, if possible. * * @param WP_REST_Request $request * @return WP_Error|WP_REST_Response */ public static function delete_key( $request ) { if ( defined( 'WPCOM_API_KEY' ) ) { return rest_ensure_response( new WP_Error( 'hardcoded_key', __( 'This site\'s API key is hardcoded and cannot be deleted.', 'akismet' ), array( 'status'=> 409 ) ) ); } delete_option( 'wordpress_api_key' ); return rest_ensure_response( true ); } /** * Get the Akismet settings. * * @param WP_REST_Request $request * @return WP_Error|WP_REST_Response */ public static function get_settings( $request = null ) { return rest_ensure_response( array( 'akismet_strictness' => ( get_option( 'akismet_strictness', '1' ) === '1' ), 'akismet_show_user_comments_approved' => ( get_option( 'akismet_show_user_comments_approved', '1' ) === '1' ), ) ); } /** * Update the Akismet settings. * * @param WP_REST_Request $request * @return WP_Error|WP_REST_Response */ public static function set_boolean_settings( $request ) { foreach ( array( 'akismet_strictness', 'akismet_show_user_comments_approved', ) as $setting_key ) { $setting_value = $request->get_param( $setting_key ); if ( is_null( $setting_value ) ) { // This setting was not specified. continue; } // From 4.7+, WP core will ensure that these are always boolean // values because they are registered with 'type' => 'boolean', // but we need to do this ourselves for prior versions. $setting_value = Akismet_REST_API::parse_boolean( $setting_value ); update_option( $setting_key, $setting_value ? '1' : '0' ); } return self::get_settings(); } /** * Parse a numeric or string boolean value into a boolean. * * @param mixed $value The value to convert into a boolean. * @return bool The converted value. */ public static function parse_boolean( $value ) { switch ( $value ) { case true: case 'true': case '1': case 1: return true; case false: case 'false': case '0': case 0: return false; default: return (bool) $value; } } /** * Get the Akismet stats for a given time period. * * Possible `interval` values: * - all * - 60-days * - 6-months * * @param WP_REST_Request $request * @return WP_Error|WP_REST_Response */ public static function get_stats( $request ) { $api_key = Akismet::get_api_key(); $interval = $request->get_param( 'interval' ); $stat_totals = array(); $request_args = array( 'blog' => get_option( 'home' ), 'key' => $api_key, 'from' => $interval, ); $request_args = apply_filters( 'akismet_request_args', $request_args, 'get-stats' ); $response = Akismet::http_post( Akismet::build_query( $request_args ), 'get-stats' ); if ( ! empty( $response[1] ) ) { $stat_totals[$interval] = json_decode( $response[1] ); } return rest_ensure_response( $stat_totals ); } /** * Get the current alert code and message. Alert codes are used to notify the site owner * if there's a problem, like a connection issue between their site and the Akismet API, * invalid requests being sent, etc. * * @param WP_REST_Request $request * @return WP_Error|WP_REST_Response */ public static function get_alert( $request ) { return rest_ensure_response( array( 'code' => get_option( 'akismet_alert_code' ), 'message' => get_option( 'akismet_alert_msg' ), ) ); } /** * Update the current alert code and message by triggering a call to the Akismet server. * * @param WP_REST_Request $request * @return WP_Error|WP_REST_Response */ public static function set_alert( $request ) { delete_option( 'akismet_alert_code' ); delete_option( 'akismet_alert_msg' ); // Make a request so the most recent alert code and message are retrieved. Akismet::verify_key( Akismet::get_api_key() ); return self::get_alert( $request ); } /** * Clear the current alert code and message. * * @param WP_REST_Request $request * @return WP_Error|WP_REST_Response */ public static function delete_alert( $request ) { delete_option( 'akismet_alert_code' ); delete_option( 'akismet_alert_msg' ); return self::get_alert( $request ); } private static function key_is_valid( $key ) { $request_args = array( 'key' => $key, 'blog' => get_option( 'home' ), ); $request_args = apply_filters( 'akismet_request_args', $request_args, 'verify-key' ); $response = Akismet::http_post( Akismet::build_query( $request_args ), 'verify-key' ); if ( $response[1] == 'valid' ) { return true; } return false; } public static function privileged_permission_callback() { return current_user_can( 'manage_options' ); } /** * For calls that Akismet.com makes to the site to clear outdated alert codes, use the API key for authorization. */ public static function remote_call_permission_callback( $request ) { $local_key = Akismet::get_api_key(); return $local_key && ( strtolower( $request->get_param( 'key' ) ) === strtolower( $local_key ) ); } public static function sanitize_interval( $interval, $request, $param ) { $interval = trim( $interval ); $valid_intervals = array( '60-days', '6-months', 'all', ); if ( ! in_array( $interval, $valid_intervals ) ) { $interval = 'all'; } return $interval; } public static function sanitize_key( $key, $request, $param ) { return trim( $key ); } /** * Process a webhook request from the Akismet servers. * * @param WP_REST_Request $request * @return WP_Error|WP_REST_Response */ public static function receive_webhook( $request ) { Akismet::log( array( 'Webhook request received', $request->get_body() ) ); /** * The request body should look like this: * array( * 'key' => '1234567890abcd', * 'endpoint' => '[comment-check|submit-ham|submit-spam]', * 'comments' => array( * array( * 'guid' => '[...]', * 'result' => '[true|false]', * 'comment_author' => '[...]', * [...] * ), * array( * 'guid' => '[...]', * [...], * ), * [...] * ) * ) * * Multiple comments can be included in each request, and the only truly required * field for each is the guid, although it would be friendly to include also * comment_post_ID, comment_parent, and comment_author_email, if possible to make * searching easier. */ // The response will include statuses for the result of each comment that was supplied. $response = array( 'comments' => array(), ); $endpoint = $request->get_param( 'endpoint' ); switch ( $endpoint ) { case 'comment-check': $webhook_comments = $request->get_param( 'comments' ); if ( ! is_array( $webhook_comments ) ) { return rest_ensure_response( new WP_Error( 'malformed_request', __( 'The \'comments\' parameter must be an array.', 'akismet' ), array( 'status' => 400 ) ) ); } foreach ( $webhook_comments as $webhook_comment ) { $guid = $webhook_comment['guid']; if ( ! $guid ) { // Without the GUID, we can't be sure that we're matching the right comment. // We'll make it a rule that any comment without a GUID is ignored intentionally. continue; } // Search on the fields that are indexed in the comments table, plus the GUID. // The GUID is the only thing we really need to search on, but comment_meta // is not indexed in a useful way if there are many many comments. This // should help narrow it down first. $queryable_fields = array( 'comment_post_ID' => 'post_id', 'comment_parent' => 'parent', 'comment_author_email' => 'author_email', ); $query_args = array(); $query_args['status'] = 'any'; $query_args['meta_key'] = 'akismet_guid'; $query_args['meta_value'] = $guid; foreach ( $queryable_fields as $queryable_field => $wp_comment_query_field ) { if ( isset( $webhook_comment[ $queryable_field ] ) ) { $query_args[ $wp_comment_query_field ] = $webhook_comment[ $queryable_field ]; } } $comments_query = new WP_Comment_Query( $query_args ); $comments = $comments_query->comments; if ( ! $comments ) { // Unexpected, although the comment could have been deleted since being submitted. Akismet::log( 'Webhook failed: no matching comment found.' ); $response['comments'][ $guid ] = array( 'status' => 'error', 'message' => __( 'Could not find matching comment.', 'akismet' ) ); continue; } if ( count( $comments ) > 1 ) { // Two comments shouldn't be able to match the same GUID. Akismet::log( 'Webhook failed: multiple matching comments found.', $comments ); $response['comments'][ $guid ] = array( 'status' => 'error', 'message' => __( 'Multiple comments matched request.', 'akismet' ) ); continue; } else { // We have one single match, as hoped for. Akismet::log( 'Found matching comment.', $comments ); $current_status = wp_get_comment_status( $comments[0] ); $result = $webhook_comment['result']; if ( 'true' == $result ) { Akismet::log( 'Comment should be spam' ); // The comment should be classified as spam. if ( 'spam' != $current_status ) { // The comment is not classified as spam. If Akismet was the one to act on it, move it to spam. if ( Akismet::last_comment_status_change_came_from_akismet( $comments[0]->comment_ID ) ) { Akismet::log( 'Comment is not spam; marking as spam.' ); wp_spam_comment( $comments[0] ); Akismet::update_comment_history( $comments[0]->comment_ID, '', 'webhook-spam' ); } else { Akismet::log( 'Comment is not spam, but it has already been manually handled by some other process.' ); Akismet::update_comment_history( $comments[0]->comment_ID, '', 'webhook-spam-noaction' ); } } } else if ( 'false' == $result ) { Akismet::log( 'Comment should be ham' ); // The comment should be classified as ham. if ( 'spam' == $current_status ) { Akismet::log( 'Comment is spam.' ); // The comment is classified as spam. If Akismet was the one to label it as spam, unspam it. if ( Akismet::last_comment_status_change_came_from_akismet( $comments[0]->comment_ID ) ) { Akismet::log( 'Akismet marked it as spam; unspamming.' ); wp_unspam_comment( $comments[0] ); akismet::update_comment_history( $comments[0]->comment_ID, '', 'webhook-ham' ); } else { Akismet::log( 'Comment is not spam, but it has already been manually handled by some other process.' ); Akismet::update_comment_history( $comments[0]->comment_ID, '', 'webhook-ham-noaction' ); } } } $response['comments'][ $guid ] = array( 'status' => 'success' ); } } break; case 'submit-ham': case 'submit-spam': // Nothing to do for submit-ham or submit-spam. break; default: // Unsupported endpoint. break; } /** * Allow plugins to do things with a successfully processed webhook request, like logging. * * @since 5.3.2 * * @param WP_REST_Request $request The REST request object. */ do_action( 'akismet_webhook_received', $request ); Akismet::log( 'Done processing webhook.' ); return rest_ensure_response( $response ); } } Bristol Myers Squibb to buy Karuna Therapeutics | Modern Business International
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Saturday, June 14, 2025
HomeNewsBristol Myers Squibb to buy Karuna Therapeutics

Bristol Myers Squibb to buy Karuna Therapeutics

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Bristol Myers Squibb on Friday announced it agreed to buy biopharmaceutical company Karuna Therapeutics for $14 billion in cash, or $330 per share.

Karuna’s stock closed up more than 47% on the news Friday, hitting $317.85 a share. Bristol Myers Squibb shares closed up 2%.

The deal will help expand Bristol Myers’ drug pipeline after competition from a generic offering caused demand for the company’s blood cancer drug Revlimid to tumble in its third quarter.

The boards of directors at both Bristol Myers and Karuna unanimously approved the acquisition, and it is expected to close in the first half of 2024, according to a release.

Karuna develops medications for patients living with neurological and psychiatric conditions. The company’s lead asset is an antipsychotic called KarXT, which is expected to serve as a treatment for adults with schizophrenia beginning in late 2024, the release said.  

“There are tremendous opportunities in neuroscience, and Karuna strengthens our position and accelerates the expansion and diversification of our portfolio in the space. We expect KarXT to enhance our growth through the late 2020s and into the next decade,” Bristol Myers Squibb CEO Christopher Boerner said in a statement.

KarXT is also being evaluated as a possible treatment for Alzheimer’s disease psychosis and a form of bipolar disorder, according to the release. Karuna CEO Bill Meury said the company’s portfolio “offers advancements in treatment not seen in many years.”

“With Bristol Myers Squibb’s long-standing expertise in developing and commercializing medicines on a global scale and legacy in neuroscience, KarXT and the other assets in our pipeline will be well-positioned to reach those living with schizophrenia and Alzheimer’s disease psychosis,” he said in a statement. 

Citi and Gordon Dyal & Co. advised Bristol Myers on the deal, while Goldman Sachs served as the exclusive advisor for Karuna.

— CNBC’s Annika Kim Constantino contributed to this report.

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